林兴

林兴教授

个人简介
主要从事肝纤维化的基础研究工作，先后主持了与肝纤维化研究相关的国家自然科学基金课题3项、省级课题3项；以通讯或第一作者发表SCI论文29篇（总的影响因子为 90.93，被引用435次，IF5.0以上有3篇）、中文核心期刊论文26篇；获得国家授权发明专利3项；获得广西自然科学奖二等奖1项（排名第2）、广西科技进步奖三等奖1项（排名第3）、中国药学会科学技术奖三等奖1项（排名第3）。

研究方向：
1. 民族药抗肝纤维化研究
2. 中药活性成分抗脂肪肝的研究

科研项目：
近5年主持的纵向省级以上科研课题6项，经费200万元。
1. Raf 激酶抑制蛋白在肝纤维化发生机制中的调控作用，国家自然科学基金，批准号：81260505，55万元，主持。
2. 从TGF-β1/Smads、ERK信号途径探讨山芝麻酸甲酯抗肝纤维化的作用机制，国家自然科学基金，批准号：81473431，73万元，主持。
3. 基于PI3K/Akt信号通路探讨鹅不食草心菊内酯抑制肝纤维化的作用机制，国家自然科学基金，批准号：81660693，直接经费36万元，主持。
4. 鹅不食草心菊内酯抗肝纤维化的作用及其机制研究，广西自然科学基金重点项目，批准号：2016GXNSFDA380025，经费30万无，主持。
5. 山芝麻酸甲酯介导ERK 信号传导通路对肝纤维化的抑制作用机制，广西自然科学基金面上项目，批准号：2014GXNSFAA118154，经费5万无，主持。
6. 基于Raf-1/MEK/ERK1,2 信号通路研究RKIP 在肝纤维化中的调控作用，广西自然科学基金面上项目，批准号：2013GXNSFAA019150，经费5万无，主持。

代表论著：
近5年，以通讯或第一作者发表SCI论文29篇
1. Bai F, Huang QF, Wei JB, Lv SJ, Chen YX, Liang CH, Wei L, Lu ZP, Lin X*. Gypsophila elegans isoorientin-2″-O-α-L-arabinopyranosyl ameliorates porcine serum-induced immune liver fibrosis by inhibiting NF-κB signaling pathway and suppressing HSC activation. International Immunopharmacology. 2018, 54: 60-67 (IF 2.956) (通讯作者)  
2. Huang QF, Bai F, Nie J, Lu S, Lu C, Zhu X, Zhuo L, Lu Z, Lin X*. Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression. International Immunopharmacology. 2017, 42: 130-138 (IF 2.956) (通讯作者)  
3. Wei J1, Huang QF1, Bai F, Lin J, Nie J, Lu S, Lu C, Huang R, Lu Z, Lin X*. Didymin induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells. Chemico-Biological Interactions. 2017, 261(5): 118-126 (IF 3.143) (通讯作者)  
4. Bai F, Huang QF, Nie JL, Lu SJ, Lu CY, Zhu XS, Wang YX, Zhuo L, Lu ZP, Lin X*. Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy. Cellular Physiology and Biochemistry. 2017, 44: 436-446 (IF 5.104) (通讯作者)
5. Lin X, Wei JB, Chen YX, He P, Lin J, Tan SM, Nie JL, Lu SJ, He M, Lu ZP, Huang QF*, Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway. Journal of Ethnopharmacology. 2016, 187: 187–194 (IF 2.981) (第一作者)
6. Huang QF, Wei L, Liang C, Nie J, Lu S, Lu C, Tan S, Lv S, Zhuo L, Lu Z, Lin X*. Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis. Biomedicine & Pharmacotherapy. 2016, 82: 669-676 (IF 2.759) (通讯作者)  
7. Huang QF, Liang C, Wei L, Nie J, Lu S, Lu C, Tan S, Lv S, Zhuo L, Lu Z, Lin X*. Raf kinase inhibitory protein down- expression exacerbates hepatic fibrosis In Vivo and In Vitro. Cellular Physiology and Biochemistry. 2016, 40:49-61 (IF 5.104) (通讯作者)  
8. Lin X, Bai F, Nie J, Lu S, Lu C, Zhu X, Wei J, Lu Z, Huang QF*. Didymin alleviates hepatic fibrosis through inhibiting ERK and PI3K/Akt pathways via regulation of Raf kinase inhibitor protein. Cellular Physiology and Biochemistry. 2016, 40: 1422 -1432 (IF 5.104) (第一作者)  
9. Wei L, Lv SJ, Huang QF, Wei JB, Zhang SJ, Huang RB, Lu ZP, Lin X*. Pratensein attenuates Aβ-induced cognitive deficits in rats: Enhancement of synaptic plasticity and cholinergic function. Fitoterapia. 2015, 101: 208-217 (IF 2.698) (通讯作者)  
10. Liang CH, Tan SM, Huang QF, Lin J, Lu ZP, Lin X*. Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels. Neuroscience Letters. 2015, 592: 48–53 (IF 2.18) (通讯作者)  
11. Lin X, Chen Y, Lv S, Tan S, Zhang S, Huang R, Zhuo L, Liang S, Lu Z, Huang QF*. Gypsophila elegans isoorientin attenuates CCl4-induced hepatic fibrosis in rats via modulation of NF-κB and TGF-β1/Smad signaling pathways. International immunopharmacology. 2015 Jun 25, 28 (1): 305-312. (IF 2.956) (第一作者)
12. Lin X1, Huang ZS1, Chen XY, Rong YP, Zhang SJ, Jiao Y, Huang QF, Huang RB*. Protective effect of Millettia pulchra polysaccharide on cognitive impairment induced by d-galactose in mice. Carbohydrate polymers. 2014, 101: 533-543 (IF 4.811) (并列第一作者)  
13. Lin X, Zhang SJ, Huang RB, Tan S, Liang S, Wu X, Zhuo L, Huang QF*. Protective effect of tormentic acid from Potentilla chinensis against lipopolysaccharide/D-galactosamine induced fulminant hepatic failure in mice. International Immunopharmacology, 2014, 19：365-372 (IF 2.956) (第一作者)  
14. Lin X, Zhang SJ, Huang RB, Wei L, Liang C, Chen Y, Lv S, Liang S, Wu X, Huang QF*. Protective Effect of Genistein on Lipopolysaccharide/D-galactosamine-induced Hepatic Failure in Mice. Biological and pharmaceutical bulletin. 2014, 37 (4): 1-8  (IF 1.574) (第一作者)  
15. Lin X, Zhang SJ, Huang RB, Wei L, Tan S, Liang S, Tian YC, Wu XY, Lu ZP, Huang QF*. Helenalin attenuates alcohol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and suppressing HSC activation. Fitoterapia. 2014, 95: 203-213 (IF 2.698) (第一作者)  
16. Lin X, Zhang SJ, Huang RB, Wei L, Tan S, Liang C, Lv S, Chen Y, Liang S, Tian Y, Lu Z, Huang QF*. Protective effect of madecassoside against cognitive impairment induced by D-galactose in mice. Pharmacology, Biochemistry and Behavior. 2014, 124: 343-442 (IF 2.537) (第一作者)  
17. Huang QF, Huang RB, Wei L, Chen Y, Lv S, Liang C, Zhang X, Yin F, Li HT, Zhuo L, Lin X*. Antiviral activity of methyl helicterate isolated from Helicteres angustifolia (Sterculiaceae) against hepatitis B virus. Antiviral research. 100 (2): 373-381, 2013 (IF 4.909) (通讯作者)  
18. Huang QF, Huang RB, Zhang ZJ, Lin J, Wei L, He M, Zhuo L, Lin X*. Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats. Toxicology Letters. 217(2): 102-110, 2013 (IF 3.522) (通讯作者)  
19. Huang QF, Zhang SJ, Huang RB, Wei L, Chen Y, Lv S, Liang C, Tan S, Zhuo L, Lin X*. Isolation and identification of an anti-hepatitis B virus compound from Hydrocotyle sibthorpioides Lam. Journal of ethnopharmacology. 150 (2): 568-575, 2013 (IF 2.981) (通讯作者)  
20. Lin X, Huang RB, Zhang SJ, Wei L, Zhuo L, Wu X, Tang A, Huang QF*. Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice. Fitoterapia. 87: 69-77, 2013 (IF 2.698) (第一作者)  
21. Wei J, Huang QF, Huang RB, Chen Y, Lv S, Wei L, Liang C, Liang S, Zhuo L, Lin X*. Asiatic acid from Potentilla chinensis attenuate ethanol-induced hepatic injury via suppression of oxidative stress and Kupffer cell activation. Biological & pharmaceutical bulletin. 36 (12): 1980-1989, 2013 (IF 1.574) (通讯作者)  
22. Huang QF, Zhang SJ, Zheng L, Liao M, He M, Huang RB, Zhuo L, Lin X*. Protective effect of isoorientin-2″-O-α-L-arabinopyranosyl isolated from Gypsophila elegans on alcohol induced hepatic fibrosis in rats. Food and chemical toxicology. 50(6):1992-2001, 2012 (IF 3.778) (通讯作者)  
23. Huang QF, Zhang SJ, Zheng L, He M, Huang R.B, Lin X*. Hepatoprotective effects of Total Saponins Isolated from Taraphochlamys affinis against carbon tetrachloride induced liver injury in rats. Food and chemical toxicology. 50, 713-718, 2012 (IF 3.778) (通讯作者)  
24. Lin X, Huang RB, Zhang SJ, Zheng L, Wei L, He M, Zhou Y, Zhuo L, Huang QF*. Methyl helicterate protects against CCl4-induced liver injury in rats by inhibiting oxidative stress, NF-κB activation, Fas/FasL pathway and cytochrome P4502E1 level. Food and chemical toxicology. 50 (10): 3413-3420, 2012 (IF 3.778) (第一作者)  
25. Huang QF, Li YW, Zhang SJ,  Huang RB, Zheng L, Wei L, He M, Liao M, Li L, Zhuo L, Lin X*. Effect and mechanism of methyl helicterate isolated from Helicteres angustifolia (Sterculiaceae) on hepatic fibrosis induced by carbon tetrachloride in rats. Journal of Ethnopharmacology. 143 (3): 889-895, 2012 (IF 2.981) (通讯作者)  
26. Lin X, Zhang SJ, Huang QF, Wei L, Zheng L, Chen Z.N, Jiao Y, Huang JC, Fu SJ, Huang RB*. Protective effect of Fufang-Liu-Yue-Qing, a traditional Chinese herbal formula, on CCl4 induced liver fibrosis in rats. Journal of Ethnopharmacology. 142 (2):548-56, 2012 (IF 2.981) (第一作者)  
27. Zhuo L, Ming M, Zheng L, He M, Huang QF, Wei L, Huang RB, Zhang ZJ, Lin X*. Combination therapy with taurine， epigallocatechin gallate and genistein for protection against hepatic fibrosis induced by alcohol in rats. Biological and Pharmaceutical Bulletin. 35 (10), 1802-1810, 2012 (IF 1.574) (通讯作者)  
28. Lin X1, Liu X1, Huang QF, Zhang SJ, Zheng L, Wei L, He M, Jiao Y, Huang JC, Fu SJ, Chen ZN, Li YW, Zhuo L, Huang RB*. Hepatoprotective effects of the polysaccharide isolated from Tarphochlamys affinis (Acanthaceae) against CCl4-induced hepatic injury. Biological and Pharmaceutical Bulletin. 35 (9), 1574-1580, 2012 (IF 1.574) (并列第一作者)  
29. Chen1 ZN, Lin1 X, Zhang Z.W, Huang JC, Fu SJ, Huang RB*. EXO70 protein influences dengue virus secretion. Microbes and Infection, 13 (2):143-150, 2011 (IF 2.291，并列第一作者）

获得专利
（1）山芝麻提取物在制备抗肝纤维化药物中的应用，专利号：ZL201010154207.6，授权公告：2013.05（专利权人：林兴）。
（2）山芝麻提取物在制备抗乙型肝炎药物中的应用，专利号：ZL201110102153.3，授权公告：2013.07（专利权人：林兴）。
（3）满天星异荭草苷在制备治疗酒精性肝损伤药物中的应用，授权专利号：ZL201310190276.6，授权公告：2015.01（专利权人：黄权芳，林兴）。


联系方式
1. 邮箱：gxLx60@163.com
2. 办公电话：0771-5358129
3. 通讯地址：广西医科大学科技大楼5楼0523-01室